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Recent Advances in Rare Liver Diseases

In editing this focused series on the novel advances in rare and undiagnosed liver diseases, we hoped to highlight, using specific examples, the burden of these diseases, their complexity, the unmet needs for the patients and their families, as well as the opportunities to learn more about pathophysiological mechanisms and targets that can also be applied to more common liver diseases.

Advanced Endoscopic Imaging of the GI Tract

Since the introduction of fibre-optic gastroscope in the early 60s, the biggest advancement in gastrointestinal Endoscopy was the introduction of image enhanced endoscopy (IEE). The breakthrough happened when Gono and colleagues from Olympus R&D invented Narrow Band Imaging (NBI) to enhance the features of the gastrointestinal mucosa that white light endoscopy alone would not achieve.

Gastrointestinal Cancer

Globally, gastroesophageal adenocarcinomas (GEAs) impose an enormous health burden. In most of the world, diagnosis is made based on symptoms and not potential risk. This leads to high number of cases with advanced cancer at diagnosis. Advanced GEA patients face especial challenges such as nutritional deficiency, anemia, low-grade chronic bleeding, peritoneal carcinomatosis, and ovarian metastases (in females) in conjunction with lack of effective therapeutic options.

Non-alcoholic Fatty Liver Disease and Alcoholic Liver Disease

Alcohol-associated liver disease (ALD) and non-alcoholic fatty liver disease (NAFLD) are commonest causes of chronic liver disease. In spite of different risk factor, they share common spectrum of fatty liver/steatosis, steatohepatitis, fibrosis, cirrhosis, and hepatocellular carcinoma.

AME entered an official partnership with Publons to enhance wide-ranging recognition for reviewers

AME Publishing Company entered an official partnership with Publons, a product of Clarivate Analytic Company (which owns Web of Science, EndNote, ScholarOne, among many others), as of April 2020. Around 60 AME journals’ peer review systems are now integrated seamlessly into the Publons platform (https://publons.com/about/home). The partnership was done to recognize our expert peer reviewers spontaneously for their review contribution.

Implementation of transparent peer review at Translational Gastroenterology and Hepatology

With a commitment to openness and accountability, and to increase the level of transparency throughout our peer review process, our editorial office has decided to implement a transparent peer review process as an option for all manuscripts submitted to TGH from March 19, 2020.

TGH Annual Report 2019

Greetings from the editorial office of Translational Gastroenterology and Hepatology(TGH).

We are pleased to present TGH's Annual Report for the year of 2019 here. In summary, TGH has published 84 articles with original articles and review articles accounting for 56% of the publication. The total citation of TGH has increased from 216 (2018) to 415 (2019). The average monthly pageviews of TGH in 2019 is 9099, compared to 5271 in 2018.

Application of the CARE Guideline as reporting standard in Translational Gastroenterology and Hepatology

Translational Gastroenterology and Hepatology welcomes case reports which are supposed to report new observations of diseases, clinical findings or novel/unique treatment outcomes relevant to practitioners in the fields of medicine.

For completeness and transparency for published case reports, Translational Gastroenterology and Hepatology will apply the CARE guidelines (1) as reporting standards for case reports starting from October 14, 2019.

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Review Article

Video capsule endoscopy: pushing the boundaries with software technology

Frank Phillips, Sabina Beg

Translational Gastroenterology and Hepatology

2021;

(05 January 2021)

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Review Article

Advances in the surgical management of gastric and gastroesophageal junction cancer

Raja R. Narayan, George A. Poultsides

Translational Gastroenterology and Hepatology

2021;

(05 January 2021)

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Review Article

Barrier therapies supporting the biology of the mucosal barrier- medical devices for common clinical mucosal disorders

Ricky W. McCullough

Translational Gastroenterology and Hepatology

2021;

(05 January 2021)

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Review Article

Barrett’s esophagus: current standards in advanced imaging

Jennifer M. Kolb, Sachin Wani

Translational Gastroenterology and Hepatology

2021;

(05 January 2021)

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Review Article

Metabolic syndrome following liver transplantation in nonalcoholic steatohepatitis

Zachary Spiritos, Manal F. Abdelmalek

Translational Gastroenterology and Hepatology

2021;

(05 January 2021)

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Review Article

Colon cancer and immunotherapy—can we go beyond microsatellite instability?

Rimini Breakstone

Translational Gastroenterology and Hepatology

2021;

(05 January 2021)

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Original Article

Comparison between Milan and UCSF criteria for liver transplantation in patients with hepatocellular carcinoma: a systematic review and meta-analysis

Jorge Henrique Bento de Sousa, Igor Lepski Calil, Francisco Tustumi, Douglas da Cunha Khalil, Guilherme Eduardo Gonçalves Felga, Rafael Antonio de Arruda Pecora, Marcio Dias de Almeida

Translational Gastroenterology and Hepatology

2021;

(05 January 2021)

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Original Article

Modified frailty index predicts complications and death after non-bariatric gastrectomies

Konstantinos A. Zorbas, Vic Velanovich, Nestor F. Esnaola, Andreas Karachristos

Translational Gastroenterology and Hepatology

2021;

(05 January 2021)

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Original Article

A pilot study of estrogen receptor (ER) expression in pancreatic ductal adenocarcinoma (PDAC)

Kai Siang Chan, Bernard Chi Shern Ho, Vishal G. Shelat

Translational Gastroenterology and Hepatology

2021;

(05 January 2021)

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Original Article

The Psychometric Hepatic Encephalopathy Syndrome score does not correlate with blood ammonia, endotoxins or markers of inflammation in patients with cirrhosis

Nina Kimer, Lise Lotte Gluud, Julie Steen Pedersen, Juliette Tavenier, Søren Møller, Flemming Bendtsen

Translational Gastroenterology and Hepatology

2021;

(05 January 2021)

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Editorial

Artificial intelligence and the endoscopist’s skill and proficiency for polyp detection: no winner one without the other!

Franco Radaelli, Silvia Paggi

Translational Gastroenterology and Hepatology

2021;

(05 January 2021)

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Editorial

Pancreatic cancer and immune checkpoint inhibitors—still a long way to go

Jessica Bian, Khaldoun Almhanna

Translational Gastroenterology and Hepatology

2021;

(05 January 2021)

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Review Article

Basic science to clinical trials in non-alcoholic fatty liver disease and alcohol-related liver disease: collaboration with industry

Amon Asgharpour, Amreen Dinani, Scott L. Friedman

Translational Gastroenterology and Hepatology

2021;

(05 January 2021)

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Review Article

Mitochondrial dysfunction in nonalcoholic fatty liver disease and alcohol related liver disease

Pankaj Prasun, Ilona Ginevic, Kimihiko Oishi

Translational Gastroenterology and Hepatology

2021;

(05 January 2021)

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Review Article

Gut microbiome changes in Nonalcoholic fatty liver disease & alcoholic liver disease

Eric K. Kwong, Puneet Puri

Translational Gastroenterology and Hepatology

2021;

(05 January 2021)

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Review Article

Genetic and epigenetic disease modifiers: non-alcoholic fatty liver disease (NAFLD) and alcoholic liver disease (ALD)

Narendra Singh Choudhary, Ajay Duseja

Translational Gastroenterology and Hepatology

2021;

(05 January 2021)

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Editorial

Similarities and differences between non-alcoholic fatty liver disease (NAFLD) & alcohol-associated liver disease (ALD)

Ashwani K. Singal

Translational Gastroenterology and Hepatology

2021;

(05 January 2021)

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Review Article

Molecular biology and immunology of gastric cancer peritoneal metastasis

Xiaodan Yao, Jaffer A. Ajani, Shumei Song

Translational Gastroenterology and Hepatology

2020;

(05 October 2020)

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Review Article

Next generation sequencing in gastric or gastroesophageal adenocarcinoma

Geoffrey Y. Ku

Translational Gastroenterology and Hepatology

2020;

(05 October 2020)

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Review Article

Gastrointestinal cancers: current biomarkers in esophageal and gastric adenocarcinoma

Purabi Dhakras, Nataliya Uboha, Vanessa Horner, Erica Reinig, Kristina A. Matkowskyj

Translational Gastroenterology and Hepatology

2020;

(05 October 2020)

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Case Report

An unusual and challenging cause of small bowel bleeding: Isolated gastrointestinal blue rubber bleb nevus syndrome

Yala Kirthi Reddy, Mahmoud Bayoumi, Matthew Barnes, William Gillespie, Faisal Kamal, Mohammad Ismail, Muhammad Bilal

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Endoscopic stricturotomy with pulsed argon plasma and balloon dilation for refractory benign colorectal strictures: a case series

Saad Emhmed Ali, Avinash Bhakta, Robert-Marlo Bautista, Ahmed Sherif, Wesam Frandah

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Undiagnosed liver diseases

Emily Gao, Julian Hercun, Theo Heller, Sílvia Vilarinho

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Editorial

Value of alpha-fetoprotein in hepatocellular carcinoma

Wei-Chen Lee

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Impediments to therapeutic advances for patients with gastroesophageal adenocarcinoma

Jaffer A. Ajani

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A primer to image enhanced endoscopy

Krish Ragunath, Philip Chiu

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Rare and undiagnosed liver diseases: challenges and opportunities

Luca Fabris, Mario Strazzabosco

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Filling the diagnostic gap in follow-up after liver transplantation

Christoph Eisenbach

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Editorial Commentary

Laparoscopic for advanced gastric cancer—minimally invasive for maximal results?

Mickael Chevallay, Charles-Henri Wassmer, Marco Bonino, Stefan Mönig

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Original Article

Predictors of poor bowel preparations and colonoscopy cancellations in inpatient colonoscopies, a single center retrospective study

Rohit Agrawal, Muhammad Majeed, Bashar M. Attar, Estefania Flores, Zohaib Haque, Sheeba Ba Aqeel, Yuchen Wang, Yazan Abu Omar, Pradeep Parajuli, Melchor Demetria, Seema Gandhi

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Pathophysiology of gastroesophageal reflux disease—which factors are important?

Karl-Hermann Fuchs, Arielle M. Lee, Wolfram Breithaupt, Gabor Varga, Benjamin Babic, Santiago Horgan

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Diagnostic performance of volumetric laser endomicroscopy for Barrett’s esophagus dysplasia amongst gastroenterology trainees

Muhammad Aziz, Chandra S. Dasari, Tarun Rai, Benjamin Alsop, Neil Gupta, Prashanth Vennalaganti, Viveksandeep Thoguluva Chandrasekar, Kelsey Able, Kevin Kennedy, Michael B. Wallace, Kenneth K. Wang, Herbert C. Wolfsen, Prateek Sharma, Cadman L. Leggett

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Post-cholecystectomy syndrome: a retrospective study analysing the associated demographics, aetiology, and healthcare utilization

Saad Saleem, Simcha Weissman, Hector Gonzalez, Patricia Guzman Rojas, Faisal Inayat, Ali Alshati, Vinaya Gaduputi

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Clinical and laboratory parameters associated with li-rads as diagnostic of liver nodule in patients with cirrhosis

Clarissa Rocha Cruz, Ana Rita Marinho Ribeiro Carvalho, Augusto César Nascimento Maranhão, Dayse Barbosa Aroucha, Gabriela Azevedo Foinquinos, Sylene Rampche Coutinho Carvalho, Luydson Richardson Silva Vasconcelos, Leila Maria Moreira Beltrão Pereira

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Wnt ligands 3a and 5a regulate proliferation and migration in human fetal liver progenitor cells

Zhiwen Liu, Vijay kumar Kuna, Bo Xu, Suchitra Sumitran-Holgersson

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Evaluating quality and completeness of gastrectomy for gastric cancer: review of surgical videos from the public domain

Matthew Dixon, Vanessa Palter, Savtaj Brar, Natalie Coburn

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The value of liquid biopsy in the diagnosis and staging of hepatocellular carcinoma: a systematic review

Poh Tan, Lisa Grundy, Peter Makary, Khem Hua Eng, George Ramsay, Mohamed Bekheit

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Palm tocotrienol rich fraction with palm kernel oil supplementation prevents development of liver steatosis in high fat diet ICR mice

Mohd Danial Mohd Efendy Goon, Nur Izzati Zulkanain, Siti Hamimah Sheikh Abdul Kadir, Sharaniza Ab Rahim, Musalmah Mazlan, Normala Abd Latip, Mardiana Abdul Aziz, Norizal Mohd Noor

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Same-day discharge vs. observation after laparoscopic pediatric appendectomy: a prospective cohort study

Kristin M. Gee, Sandra Ngo, Lorrie Burkhalter, Alana L. Beres

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What are the participants’ perspective and the system-based impact of a standardized, inter-professional morbidity/mortality- conferences in a children’s hospital?

Martin Stocker, Philipp Szavay, Birgit Wernz, Thomas J. Neuhaus, Dirk Lehnick, Sabine Zundel

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Spleen transient elastography predicts actuarial survival after liver transplantation

Kilian Friedrich, Arianeb Mehrabi, Jan Pfeiffenberger, Christian Rupp, Karl Heinz Weiss, Markus Mieth

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A retrospective comparison of outcomes for open vs. laparoscopic surgical techniques in pediatric ulcerative colitis

Brent A. Willobee, Jennifer A. Nguyen, Anthony Ferrantella, Hallie J. Quiroz, Anthony R. Hogan, Ann-Christina Brady, Samir Pandya, Amber H. Langshaw, Juan E. Sola, Chad M. Thorson, Eduardo A. Perez

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Efficacy and safety of endoscopic ultrasound-guided radiofrequency ablation for management of pancreatic lesions: a systematic review and meta-analysis

Yazan Fahmawi, Ansh Mehta, Haneen Abdalhadi, Lindsey Merritt, Meir Mizrahi

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Prophylactic colectomy for children with familial adenomatous polyposis: resource utilization and outcomes for open and laparoscopic surgery

Anthony Ferrantella, Rebecca A. Saberi, Brent A. Willobee, Hallie J. Quiroz, Amber H. Langshaw, Samir Pandya, Chad M. Thorson, Juan E. Sola, Eduardo A. Perez

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Azithromycin versus erythromycin infusions prior to endoscopy in upper gastrointestinal bleeding

Danny Issa, Sanjeev Solomon, Jonathan Hillyard, Brian Di Pace, Christopher Young, Patricia Uber, Adam Sima, Reem Sharaiha, George Smallfield

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A retrospective analysis of pancreas operations in children

R. Ellen Jones, Jessica A. Zagory, Micah Tatum, Wei Shan Tsui, Joseph Murphy

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Procalcitonin and C-reactive protein in the diagnosis of spontaneous bacterial peritonitis

Rajanshu Verma, Sanjaya K. Satapathy, Muhammad Bilal

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Biliary hyperkinesia in adolescents—it isn’t all hype!

Maggie E. Bosley, Jillian Jacobson, Michaela W. G. Gaffley, Michael A. Beckwith, Samir R. Pandya, James S. Davis, Lucas P. Neff

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Use of hem-o-lok clips for laparoscopic appendectomy in children: retrospective analysis and comparison to ligature loop and endoscopic surgical stapler

Ennio J. Fuentes, Eduardo A. Pérez, Ricardo Díez, Pablo Aguado, Cecilia Moreno, Henar Souto, Jose L. Alonso

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Characterizing a CT esophagram protocol after flexible endoscopic diverticulotomy for Zenker’s diverticulum: a retrospective series

Debdeep Banerjee, Laura L. Magnelli, Mailin Oliva, Neha Malik, Brittney M. Ginsburg, Joseph R. Grajo, Tony S. Brar, Donevan R. Westerveld, Dennis Yang, Peter V. Draganov

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Review Article

Shifting sands: the role of radiotherapy for patients with gastric and gastroesophageal adenocarcinoma

Ethan B. Ludmir, Prajnan Das

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Alpha-1 antitrypsin deficiency liver disease

Dhiren Patel, Shannon L. McAllister, Jeffrey H. Teckman

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Rectal Dieulafoy’s lesion: a comprehensive review of patient characteristics, presentation patterns, diagnosis, management, and clinical outcomes

Faisal Inayat, Amna Hussain, Sidra Yahya, Simcha Weissman, Nuraiz Sarfraz, Muhammad Salman Faisal, Iqra Riaz, Saad Saleem, Muhammad Wasif Saif

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Multimodal multidisciplinary management of alcohol use disorder in liver transplant candidates and recipients

Akhil Shenoy, Anna Salajegheh, Nicole T. Shen

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Identifying the pre-malignant stomach: from guidelines to practice

Jonathan R. White, Matthew Banks

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Enhancing polyp detection: technological advances in colonoscopy imaging

Antonio Lee, Nicholas Tutticci

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Endoscopic therapies for Barrett’s esophagus

Scott Ventre, Haroon Shahid

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New technologies for indeterminate biliary strictures

Roberto Oleas, Juan Alcívar-Vasquez, Carlos Robles-Medranda

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Evolution of the liver biopsy and its future

Dhanpat Jain, Richard Torres, Romulo Celli, Jeremy Koelmel, Georgia Charkoftaki, Vasilis Vasiliou

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Fibrosis and hepatic regeneration mechanism

Esmeralda Zuñiga Aguilar, Odin Ramírez-Fernández

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Herb-induced liver injury (HILI) with 12,068 worldwide cases published with causality assessments by Roussel Uclaf Causality Assessment Method (RUCAM): an overview

Rolf Teschke, Axel Eickhoff, Johannes Schulze, Gaby Danan

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Endoscopic bariatrics: current therapies and future directions

Debashis Reja, Clark Zhang, Avik Sarkar

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Giant cell hepatitis associated with autoimmune hemolytic anemia: an update

Silvia Nastasio, Lorenza Matarazzo, Marco Sciveres, Giuseppe Maggiore

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Confocal laser endomicroscopy in gastro-intestinal endoscopy: technical aspects and clinical applications

Nastazja Dagny Pilonis, Wladyslaw Januszewicz, Massimiliano di Pietro

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Evaluation of liver transplant candidates with non-alcoholic steatohepatitis

James Philip G. Esteban, Amon Asgharpour

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Artificial intelligence and computer-aided diagnosis for colonoscopy: where do we stand now?

Shin-ei Kudo, Yuichi Mori, Usama M. Abdel-aal, Masashi Misawa, Hayato Itoh, Masahiro Oda, Kensaku Mori

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Analysis of causality assessment methods in suspected HILI cases shows relevant gaps as assessed for accuracy, bias and transparency using data provided through the Freedom of Information Act (FOIA)

Cyril M. Willson

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Novel approaches to liver disease diagnosis and modeling

André G. Oliveira, Romina Fiorotto

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Alagille syndrome and non-syndromic paucity of the intrahepatic bile ducts

Melissa A. Gilbert, Kathleen M. Loomes

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Advances in endoscopic resection: a review of endoscopic submucosal dissection (ESD), endoscopic full thickness resection (EFTR) and submucosal tunneling endoscopic resection (STER)

Ishita Dalal, Iman Andalib

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Management of severe acute pancreatitis in 2019

Eddie Copelin, Jessica Widmer

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New and emerging technology in the diagnosis and treatment of pancreatic cysts

Lindsey C. Shipley, Ali M. Ahmed

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Electronic chromo-endoscopy: technical details and a clinical perspective

Partha Pal, Aniruddha Pratap Singh, Navya D. Kanuri, Rupa Banerjee

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Sutureless closure for the management of gastroschisis

Modupeola Diyaolu, Lauren S. Wood, Matias Bruzoni

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Fibrocystic liver disease: novel concepts and translational perspectives

Alberto Lasagni, Massimiliano Cadamuro, Giovanni Morana, Luca Fabris, Mario Strazzabosco

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Choledocholithiasis—a new clinical pathway

Maggie E. Bosley, Irving J. Zamora, Lucas P. Neff

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Liver transplantation for rare liver diseases and rare indications for liver transplant

Michele Finotti, Pasquale Auricchio, Alessandro Vitale, Enrico Gringeri, Umberto Cillo

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The acute hepatic porphyrias

Bruce Wang

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Ablative therapies of the biliary tree

Elizabeth S. John, Paul R. Tarnasky, Prashant Kedia

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Recent advances in Wilson disease

Maryam Moini, Uyen To, Michael L. Schilsky

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Current management of pediatric achalasia

Jun Tashiro, Mikael Petrosyan, Timothy D. Kane

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Bariatric surgery, obesity and liver transplantation

Zunirah Ahmed, Muhammad Ali Khan, Luis Miguel Vazquez-Montesino, Aijaz Ahmed

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Reoperative surgery in anorectal malformation patients

Timothy F. Tirrell, Erin R. McNamara, Belinda H. Dickie

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A narrative review of the modern surgical management of pediatric choledochal cysts

R. Ellen Jones, Jessica A. Zagory, Rachael A. Clark, Samir R. Pandya

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Pre-transplant portal vein thrombosis in non-alcoholic fatty liver disease patients—pathogenesis, risk factors, and implications on management

Peter DeLeeuw, Uchenna Agbim

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Implications of pre-transplant sarcopenia and frailty in patients with non-alcoholic steatohepatitis and alcoholic liver disease

Joseph S. Redman, Matt Kaspar, Puneet Puri

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Nonoperative management of appendicitis in children

Helene Nepomuceno, Erik G. Pearson

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Eosinophilic esophagitis, Barrett’s esophagus and esophageal neoplasms in the pediatric patient: a narrative review

Annette L. Medina, David M. Troendle, Jason Y. Park, Ameet Thaker, Kerry B. Dunbar, Edaire Cheng

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A narrative review of gastroesophageal reflux in the pediatric patient

Jillian C. Jacobson, Samir R. Pandya

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Reoperative techniques and management in Hirschsprung disease: a narrative review

Farokh R. Demehri, Belinda H. Dickie

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Minimally invasive surgery of the pancreas: a narrative review of current practice

Morgan K. Richards, Matthew S. Clifton

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EUS-RFA of the pancreas: where are we and future directions

Lakshmi Asritha Gollapudi, Amy Tyberg

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Enhanced recovery after surgery in children

Talha Rafeeqi, Erik G. Pearson

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Artificial intelligence in the detection, characterisation and prediction of hepatocellular carcinoma: a narrative review

Michal Kawka, Aleksander Dawidziuk, Long R. Jiao, Tamara M. H. Gall

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Narrative review of current and emerging pharmacological therapies for nonalcoholic steatohepatitis

Jinendra Satiya, Heather S. Snyder, Shivaram Prasad Singh, Sanjaya K. Satapathy

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Ethical and allocation issues in liver transplant candidates with alcohol related liver disease

Mai Sedki, Aijaz Ahmed, Aparna Goel

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Primary sclerosing cholangitis

Anahita Rabiee, Marina G. Silveira

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Therapeutic endoscopic ultrasound

Rodrigo Duarte-Chavez, Michel Kahaleh

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COVID-19 and the liver: a narrative review of the present state of knowledge

Ragesh B. Thandassery, Jonathan A. Dranoff, Abhilash Perisetti, Tamar Taddei

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Technical Note

Pancreaticoduodenectomy after Roux-en-Y Gastric Bypass: a novel reconstruction technique

Malcolm Han Wen Mak, Vishalkumar G. Shelat

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Editorial

Post-colonoscopy colorectal cancer: the key role of molecular pathological epidemiology

Tsuyoshi Hamada, Reiko Nishihara, Shuji Ogino

Regarding the applications of fusion-fluorescence imaging using indocyanine green in laparoscopic hepatectomy

Thinzar M. Lwin, Robert M. Hoffman, Michael Bouvet

Review Article

SUMOylation and phosphorylation cross-talk in hepatocellular carcinoma

Maria Lauda Tomasi, Komal Ramani

Journal Highlight more

Translational Gastroenterology and Hepatology is an international, open-access, peer-reviewed, PubMed-indexed online journal providing current and practical information on diagnosis, prevention and clinical investigations of gastrointestinal, pancreas, gallbladder and hepatic diseases.

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Translational Gastroenterology and Hepatology is published by AME Publishing Company

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About tgh

Manuscript Submission

AME Editing Service

Reprint & Permission

Contact us

General editorial enquiries:

Copyright related contact:

Commercial Sales contact (Reprints, advertising, etc.):

Case Report

Editorial

Editorial Commentary

Original Article

Review Article

Technical Note

Editorial

Review Article

Indexing

Publishing Information