Francesco Feo, MD

Division of Experimental Pathology and Oncology, Department of Clinical and Experimental Medicine, University of Sassari, Sassari, Italy

Dr. Francesco Feo is Professor Emeritus of General Pathology at the University of Sassari, Italy. He received a Medical degree from the University of Torino. After three years fellowship at the Institute of Biochemistry, of the Faculty of Medicine of the University of Strasbourg, he was designated assistant professor of Experimental Oncology at the Medical Faculty of the University of Torino and then full professor of General Pathology and director of the Division of Experimental Pathology and Oncology of the Department of Clinical and Experimental Medicine of the University of Sassari.

Dr. Feo’s research was designed to study liver carcinogenesis. His first studies focused on functional analysis of tumor mitochondria. Further work of Dr. Feo’s group focused on multistage liver carcinogenesis demonstrating, for the first time, the downregulation of the mixed function mono-oxygenases in hepatocellular carcinoma. Further pioneering studies of Dr. Feo include the role of variations in S-adenosylmethionine content in alcoholic liver injury and chemical liver carcinogenesis, chemoprevention of hepatocarcinogenesis by S-adenosylmethionine, identification of several susceptibility gene loci controlling the growth of neoplastic nodules and the signaling pathways. Importantly, these researches revealed the presence of alterations of cell cycle and signaling pathways, similar to those found in genetically susceptible rats, in human liver tumors with poorer prognosis, and the similarity of the modifications in human tumors with better prognosis with those of liver lesions of genetically resistant rats. All of these results have been published in prestigious peer reviewed journals and have been presented and discussed in international meetings and conferences.