Focused Issue on Liver injury by herbal products

Posted On 2019-11-19 06:46:24

This focused issue on “Liver injury by herbal products” is edited by Dr. Rolf Teschke from Teaching Hospital of the Goethe University of Frankfurt/Main, Germany.

Dr. Teschke was born on April 15, 1944 in Gera, a town in Eastern Germany, and studied medicine at the universities of Munich and Marburg, where he received his M.D. and finished his inaugural thesis. He is an internist with subspecialty in gastroenterology and hepatology and professor of Medicine at the Heinrich Heine University of Düsseldorf/ Germany.

His scientific and clinical interest in hepatotoxicity started as resident at the Department of Pathology, University of Marburg/Germany, with following focus on alcoholic liver disease and biochemical studies as resident at the Bronx VA Hospital/Mount Sinai Hospital in New York with Professor Charles S. Lieber during 1972-1975, appreciating living in NYC and excellent local research conditions. More specifically, here he solubilized the hepatic microsomal ethanol oxidizing system and isolated it from the other alcohol metabolizing enzymes alcohol dehydrogenase and catalase by DEAE column chromatography. Other studies included the area of cytochrome P450 and various microsomal enzymes.

Back in Germany, he had positions as resident physician and professor at the Department of Medicine, section of Gastroenterology, Hepatology, and infection at the Heinrich Heine University in Düsseldorf/ Germany. Here he finished his habilitation thesis and received a highly prized university award for his outstanding research. He undertook clinical and experimental studies focusing on hepatotoxicity by alcohol, hydrocarbons, and drugs.

Focused issue outline:

  1. Herbal traditional chinese medicines (TCM): liver injury and preexisting liver diseases as confounding variables
  2. Causality assessment in initially assumed liver injury by a herbal dietary supplement assisted by the freedom of information act (FOIA): resolved issues of cognitive bias
  3. Low prevalence of liver injury with quality controlled herbal TCMs
  4. Database for liver injury by herbs and herbal dietary supplements: case listing and new approaches to assess causality using the updated RUCAM
  5. Herb induced liver injury and the role of herbal product quality: issues of adulteration, impurities, and herbal authenticity
  6. RUCAM worldwide used for assessing causality in cases of herb induced liver injury