Donor age predicts calcineurin inhibitor induced neurotoxicity after liver transplantation

Giovanni Battista Levi Sandri, Valerio Giannelli, Giuseppe Maria Ettorre


Liver transplantation is a curative therapy for many liver diseases. Grade of liver cirrhosis is classified with the Model for End-Stage Liver Disease (MELD) score and the Child- Turcotte-Pugh score. This last one employs five clinical measures of liver disease, including hepatic encephalopathy. After liver transplantation, immunosuppressive treatments are mandatory to obtain graft survival. The commonly immunosuppressive protocol includes calcineurin inhibitor like tacrolimus, corticosteroid, and mycophenolate mofetil.