Article Abstract

Trans-arterial radio-embolization: a new chance for patients with hepatocellular cancer to access liver transplantation, a world review

Authors: Giovanni Battista Levi Sandri, Giuseppe Maria Ettorre, Valerio Giannelli, Marco Colasanti, Rosa Sciuto, Giuseppe Pizzi, Roberto Cianni, Gianpiero D’Offizi, Mario Antonini, Giovanni Vennarecci, Pierleone Lucatelli


Liver transplantation (LT) for hepatocellular carcinoma (HCC) within the Milan criteria (MC) is nowadays a curative procedure. Yttrium-90 microspheres radioembolization (Y90-RE) has shown to be an effective and safe treatment of primary liver tumors. The aim of this work is to offer a view on the publications which report on the use of Y90-RE as bridge or downstaging prior to LT. Twenty articles have been considered for this world review. About 178 LT in patients were treated with Y90-RE prior to LT. Most of patients had a downstaging strategy. In all series alpha-fetoproteins decreased between Y90-RE and LT. Therefore, Y90-RE may have an important role in the bridge and downstaging treatments.